A 12-month prospective, non-randomized registry was conducted in the 3(rd) Department of Cardiology in the Upper Silesian Medical Center in Katowice from October 2008 to April 2011. To assess bleeding and thromboembolic events depending on the antithrombotic regimen in short- and long-term follow-up in patients with AF after PCI with stent implantation.
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According to the 2010 ESC guidelines on myocardial revascularization, short-term triple antithrombotic therapy after percutaneous coronary intervention (PCI) should be given if compelling indications exist. Hence a need for use of combined anticoagulant and antithrombotic therapy has arisen. Could triple anticoagulant therapy be a solution?ĭÄ…browska, Magdalena OchaÅ‚a, Andrzej Cybulski, WiesÅ‚aw Tendera, MichaÅ‚Ītrial fibrillation (AF) has nowadays become a common disease as it comes along with medical procedures propagation in the ageing population with coexistent diseases. All rights reserved.īalancing between bleeding and thromboembolism after percutaneous coronary intervention in patients with atrial fibrillation. Adverse effects might result in poorer compliance and compromise actual ST efficacy. However, the eradication rate for ST fell from 94.4% in PP to 85% in ITT analysis. pylori eradication than HD-PPI- TT in patients with FD. Treatment compliance was similar in the HD-PPI- TT and ST groups, although nausea and dizziness were more common in the ST group. ST achieved higher cure rates than HD-PPI- TT in clarithromycin-resistant H. However, the eradication rate was significantly higher following ST compared with HD-PPI- TT in per protocol (PP) analysis (94.4% vs. Intention-to-treat (ITT) eradication rates were similar in the ST and HD-PPI- TT groups (85% vs. Eradication and antibiotic resistance rates, dyspeptic symptoms, drug compliance, and adverse effects were compared.
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pylori status was determined in post-treatment week 4 by 14 C-urea breath test. One hundred and twenty HP-FD patients were randomized to receive 10-day HD-PPI- TT (60 mg lansoprazole/500 mg clarithromycin/1 g amoxicillin, each administered twice daily for 10 days) or 10-day ST (30 mg lansoprazole/1 g amoxicillin, each administered twice daily for 5 days followed by 30 mg lansoprazole/500 mg clarithromycin/400 mg metronidazole, each administered twice daily for 5 days). pylori-associated functional dyspepsia (HP-FD). We aimed to compare the efficacy and tolerability of HD-PPI- TT and ST in H. Ten-day high-dose proton pump inhibitor triple therapy versus sequential therapy for Helicobacter pylori eradication.Īuesomwang, Chonticha Maneerattanaporn, Monthira Chey, William D Kiratisin, Pattarachai Leelakusolwong, Somchai Tanwandee, TawesakĮradication rates of Helicobacter pylori following standard triple therapy are declining worldwide, but high-dose proton-pump inhibitor-based triple therapy (HD-PPI- TT) and sequential therapy (ST) have demonstrated higher cure rates.